“If you really really really really really care ... then there ain't no time to fold 'em until your last breath is drawn—and even that's too soon if you've bothered along the way to inflame others about your presumed Quixotic cause.
In the (doubtless not) immortal words of Tom Peters: "There's a time to hold 'em and a time to keep on holdin' 'em—if you really really really care."
If you believe in something never give up!